Surface-mediated defense reactions. The plasma contact activation system.
نویسندگان
چکیده
منابع مشابه
Surface-mediated defense reactions. The plasma contact activation system.
uring the past two decades, considerable evidence has accrued that many of the body defenses against injury, specifically, blood coagulation, the inflammatory response, classical complement pathway activation, and fibrinolysis, are initiated by a common mechanism. antecedent) have been shown to be the major proteins required to initiate, amplify, and propagate surface-mediated defense reactions...
متن کاملDuring contact activation of plasma, cleavage of surface-bound Hageman
During contact activation of plasma, cleavage of surface-bound Hageman factor (HF) 1 occurs at two closely situated sites, one within a disulfide loop, termed "site 1", and one outside the disulfide loop, termed "site 2" (1). The result of these cleavages is two forms of active HF (2) which we have given the names a-HF a and fi-HFa. Fig. 1 defines these two forms based on their derivation (last...
متن کاملDissemination of Contact Activation in Plasma
Previous studies have provided evidence that during contact activation of plasma, Hageman factor (HF, clotting Factor XII) 1 binds to the negatively charged surface along with high molecular weight kininogen (HMWK). The H M W K circulates complexed at least in part with prekallikrein (PK) (1) or clotting Factor XI (2) and is instrumental in bringing both PK and clotting Factor XI to the surface...
متن کاملDissemination of contact activation in plasma by plasma kallikrein
The dissemination of contact activation of plasma was examined by measuring the cleavage of Hageman factor (HF) molecules on two separate sets of kaolin particles, one of which contained all of the components of the contact activation system, HF, prekallikrein (PK) and high molecular weight kininogen (HMWK) in whole normal plasma, and the second set of particles containing only HF and HMWK, bei...
متن کاملPhysiologic activities of the contact activation system.
The plasma contact activation (CAS) and kallikrein/kinin (KKS) systems consist of 4 proteins: factor XII, prekallikrein, high molecular weight kininogen, and the bradykinin B2 receptor. Murine genetic deletion of factor XII (F12(-/-)), prekallikrein (Klkb1(-/-)), high molecular weight kininogen (Kgn1(-/-)) and the bradykinin B2 receptor (Bdkrb2(-/-)) yield animals protected from thrombosis. Wit...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1984
ISSN: 0021-9738
DOI: 10.1172/jci111326